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A dialog between cell adhesion and topology at the core of morphogenesis
A dialog between cell adhesion and topology at the core of morphogenesis
Published: 12 May 2026 · Updated: 13 July 2026
Read the original sourceThe Critique
The paper establishes a link between local adhesion and global topology but doesn't quantify the robustness of this relationship. In real embryos, cell division, death, and rearrangement constantly change tissue topology - does the adhesion-topology relationship hold dynamically?
Why It Matters
If the adhesion-topology relationship is universal across tissue types, this could provide a unified framework for understanding morphogenetic defects in development, regeneration, and disease. But if it's embryo-specific, the applicability is limited.